USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P32119 USC-OGP 2-DE database:  P32119 P32119 General information about the entry View entry in simple text format Entry name PRDX2_HUMAN Primary accession number P32119 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Peroxiredoxin-2; EC=1.11.1.15; AltName: Full=Natural killer cell-enhancing factor B; Short=NKEF-B; AltName: Full=PRP; AltName: Full=Thiol-specific antioxidant protein; Short=TSA; AltName: Full=Thioredoxin peroxidase 1; AltName: Full=Thioredoxin-dependent peroxide reductase 1;. Gene name Name=PRDX2 Synonyms=NKEFB, TDPX1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0555: pI=5.36; Mw=21818 SPOT OGP-0562: pI=5.37; Mw=21509 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0830: pI=5.32; Mw=22641 SPOT OGP-0836: pI=5.32; Mw=19881 SPOT OGP-0839: pI=5.33; Mw=18985 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1298: pI=5.27; Mw=23825 SPOT OGP-1301: pI=5.50; Mw=22988 Cross-references UniProtKB/Swiss-Prot P32119; PRDX2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PRDX2_HUMAN Primary accession number P32119 Secondary accession number(s) A8K0C0 P31945 P32118 P35701 Q6FHG4 Q92763 Q9UC23 Sequence was last modified on  January 23, 2007 (version 5) Annotations were last modified on  March 15, 2017 (version 196) Name and origin of the protein Description RecName: Full=Peroxiredoxin-2; EC=1.11.1.15; AltName: Full=Natural killer cell-enhancing factor B; Short=NKEF-B; AltName: Full=PRP; AltName: Full=Thiol-specific antioxidant protein; Short=TSA; AltName: Full=Thioredoxin peroxidase 1; AltName: Full=Thioredoxin-dependent peroxide reductase 1; Gene name Name=PRDX2 Synonyms=NKEFB, TDPX1 Encoded on Name=PRDX2; Synonyms=NKEFB, TDPX1 Keywords 3D-structure; Acetylation; Alternative splicing; Antioxidant; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Oxidoreductase; Peroxidase; Phosphoprotein; Polymorphism; Redox-active center; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL Z22548; CAA80269.1; -; mRNA EMBL L19185; AAA50465.1; -; mRNA EMBL CR450356; CAG29352.1; -; mRNA EMBL CR541789; CAG46588.1; -; mRNA EMBL AK289485; BAF82174.1; -; mRNA EMBL DQ231563; ABB02182.1; -; Genomic_DNA EMBL AC018761; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471106; EAW84311.1; -; Genomic_DNA EMBL BC000452; AAH00452.1; -; mRNA EMBL BC003022; AAH03022.1; -; mRNA EMBL BC039428; AAH39428.1; -; mRNA EMBL X82321; CAA57764.1; -; mRNA CCDS CCDS12281.1; -. [P32119-1]; . PIR I68897; I68897; . RefSeq NP_005800.3; NM_005809.5. [P32119-1]; . UniGene Hs.432121; -; . PDB 1QMV; X-ray; 1.70 A; A/B/C/D/E/F/G/H/I/J=2-198 PDB 5B8A; X-ray; 2.70 A; A/B/C/D/E/F/G/H/I/J=46-198 PDB 5B8B; X-ray; 3.10 A; A/B/C/D/E/F/G/H/I/J=46-163 A/B/C/D/E/F/G/H/I/J=80-198 PDBsum; 1QMV; -; . PDBsum 5B8A; -; . PDBsum 5B8B; -; . ProteinModelPortal P32119; -; . SMR P32119; -; . BioGrid 112860; 99; . DIP DIP-39882N; -; . IntAct P32119; 44; . MINT MINT-3012817; -; . STRING 9606.ENSP00000301522; -; . DrugBank DB02153; 3-Sulfinoalanine; . DrugBank DB04048; N-Carbamoyl-Alanine; . PeroxiBase 4475; Hs2CysPrx02; . iPTMnet P32119; -; . PhosphoSitePlus P32119; -; . SwissPalm P32119; -; . DMDM 2507169; -; . DOSAC-COBS-2DPAGE P32119; -; . OGP P32119; -; . REPRODUCTION-2DPAGE IPI00027350; -; . SWISS-2DPAGE P32119; -; . UCD-2DPAGE P32119; -; . EPD P32119; -; . PaxDb P32119; -; . PeptideAtlas P32119; -; . PRIDE P32119; -; . TopDownProteomics P32119-1; -. [P32119-1]; . DNASU 7001; -; . Ensembl ENST00000301522; ENSP00000301522; ENSG00000167815. [P32119-1]; . GeneID 7001; -; . KEGG hsa:7001; -; . CTD 7001; -; . DisGeNET 7001; -; . GeneCards PRDX2; -; . HGNC HGNC:9353; PRDX2; . HPA CAB008713; -; . MIM 600538; gene; . neXtProt NX_P32119; -; . OpenTargets ENSG00000167815; -; . PharmGKB PA33723; -; . eggNOG KOG0852; Eukaryota; . eggNOG COG0450; LUCA; . GeneTree ENSGT00390000004653; -; . HOGENOM HOG000022343; -; . HOVERGEN HBG000286; -; . InParanoid P32119; -; . KO K03386; -; . OMA DYEVVHE; -; . OrthoDB EOG091G0IE5; -; . PhylomeDB P32119; -; . TreeFam TF105181; -; . BRENDA 1.11.1.15; 2681; . Reactome R-HSA-3299685; Detoxification of Reactive Oxygen Species; . Reactome R-HSA-5628897; TP53 Regulates Metabolic Genes; . Reactome R-HSA-8862803; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; . ChiTaRS PRDX2; human; . EvolutionaryTrace P32119; -; . GeneWiki Peroxiredoxin_2; -; . GenomeRNAi 7001; -; . PRO PR:P32119; -; . Proteomes UP000005640; Chromosome 19; . Bgee ENSG00000167815; -; . CleanEx HS_PRDX2; -; . ExpressionAtlas P32119; baseline and differential; . Genevisible P32119; HS; . GO GO:0005737; C:cytoplasm; TAS:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0016209; F:antioxidant activity; IDA:UniProtKB; . GO GO:0008379; F:thioredoxin peroxidase activity; IDA:UniProtKB; . GO GO:0045454; P:cell redox homeostasis; IEA:InterPro; . GO GO:0034599; P:cellular response to oxidative stress; IDA:BHF-UCL; . GO GO:0042744; P:hydrogen peroxide catabolic process; TAS:BHF-UCL; . GO GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB; . GO GO:0042981; P:regulation of apoptotic process; IMP:UniProtKB; . GO GO:0019430; P:removal of superoxide radicals; IDA:BHF-UCL; . GO GO:0006979; P:response to oxidative stress; IMP:UniProtKB; . GO GO:0000302; P:response to reactive oxygen species; TAS:Reactome; . Gene3D 3.40.30.10; -; 1; . InterPro IPR000866; AhpC/TSA; . InterPro IPR024706; Peroxiredoxin_AhpC-typ; . InterPro IPR019479; Peroxiredoxin_C; . InterPro IPR033046; PRDX2; . InterPro IPR012336; Thioredoxin-like_fold; . InterPro IPR013766; Thioredoxin_domain; . PANTHER PTHR10681:SF136; PTHR10681:SF136; 1; . Pfam PF10417; 1-cysPrx_C; 1; . Pfam PF00578; AhpC-TSA; 1; . PIRSF PIRSF000239; AHPC; 1; . SUPFAM SSF52833; SSF52833; 1; . PROSITE PS51352; THIOREDOXIN_2; 1; .

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